25. Norman JG, Fink GW, Denham W et al. Tissue-specific
cytokine production during experimental acute pancreatitis. A
probable mechanism for distant organ failure. Dig Dis Sci
1997; 42:1783–1788.
26. Folsch E, Serrano A, Sabatier L et al. Soluble receptors
during acute pancreatitis interfere with the detection of tumor
necrosis factor-alpha. Crit Care Med 2001; 29:1023–1026.
27. Yang J, Murphy C, Deham W et al. Evidence for a central
role for p38 map kinase induction of tumor necrosis factor
alpha in pancreatitis-associated pulmonary injury. Surgery
1999; 126:216–222.
28. Zou WG, Wang DS, Lang MF et al. Human interleukin 10
gene therapy decreases the severity and mortality of lethal
pancreatitis in rats. J Surg Res 2002; 103:121–126.
29. Dumot JA, Cowel DL, Zuccaro G et al. A randomized,
double blinded study of interleukin 10 for prevention of
ERCP-induced pancreatitis. Am J Gastroenterol 2001;
96:2098–2102.
30. Rongione AJ, Kusske AM, Kwan K et al. Interleukin 10
reduces the severity of acute pancreatitis. Gastroenterology
1997; 112:960–967.
31. Qi W, Tan DX, Reiter RJ et al. Melatonin reduced lipid
peroxidation and tissue edema in caerulein-induced acute
pancreatitis in rats. Dig Dis Sci 1999; 44:2257–2262.
32. Fujimoto K. Hosotani R, Wada M et al. Ischemia–reperfusion
injury on the pancreas in rats: identification of acinar

and 5-metoxytryptophol in the treatment of human neoplasm.
Ann N Y Acad Sci 2000; 917:560–567.

33. Jaworek J, Bonior J, Tomaszewska R et al. Involvement of
cyclooxygenase-derived prostaglandin E2and nitric oxide in
the protection of rat pancreas afforded by low dose of lipopolysaccharide.
J Physiol Pharmacol 2001; 52:107–126.
34. Jungermann J, Lerch MM, Weidenbach H et al. Disassembly
of rat pancreatic acinar cell cytoskeleton during
supramaximal secretagogue stimulation. Am J Physiol 1995;
268:G328–G338.
35. Guice KS, Oldham KT, Johnson KJ et al. Mechanisms of
pancreatic capillary endothelial injury in acute pancreatitis.
Surg Forum 1987; 28:145–149.
36. Da¸ browski A, Gabryelewicz A, Wereszczyn´ ska-
Siemia¸ tkowska U et al. Oxygen-derived free radicals in
caerulein-induced acute pancreatitis. Scand J Gastroenterol
1988; 23:1245–1249.
37. Liu J, Yeo HC, Doniger SJ et al. Assay of aldehydes from
lipid peroxydation: gas chromatography–mass spectrometry
compared to thiobarbituric acid. Anal Biochem 1997; 245:161–
166.
38. Guice KS, Miller DE, Oldham KT et al. Superoxide
dismutase and catalase a possible role in establish pancreatitis.
Am J Surg 1986; 151:163–169.
39. Niederau C, Niederau M, Borchard F et al. Effects of
antioxidants and free radical scavengers in three different
models of acute pancreatitis. Pancreas 1992; 4:130–137.
40. Luthen R, Grendell JH, Haussinger D et al. Beneficial
effects of l-2-oxothiazolidine-4-carboxylate on caerulein pancreatitis
in mice. Gastroenterology 1997; 112:1681–1691.
41. Costa EJX, Lopes RH, Lamy-Freund MT. Solubility of pure
bilayers to melatonin. J Pineal Res 1995; 19:123–126.
42. Shida CS, Castruzzi ML, Lamy-Freund MT. High melatonin
solubility in aqeous media. J Pineal Res 1994; 16:198–
201.
43. Reiter RJ. Melatonin: lowering the high price of free radicals.
News Physiol Sci 2000; 15:246–250.
44. Reiter RJ, Ta DX, Qi W, Manchester M et al. Pharmacology
and physiology of melatonin in the reduction of oxidative
stress in vivo. Biol Signals Recept 2000; 9:160–171.
45. Antunes F, Barclay RL, Tungold KU et al. On the antioxidant
activity of melatonin. Free Radic Biol Med 1999;
26:117–128.
46. Montilla P, Tunez I, Munoz MC et al. Antioxidative effect
of melatonin in rat brain oxidative stress induced by adriamycin.
Rev Esp Physiol 1997; 53:301–305.
47. Urata Y, Homma S, Goto S et al. Melatonin induces
c-glutamylcyteine synthetase mediated by activator protein-
1-human vascular endothelaial cells. Free Radic Biol Med
1999; 27:838–847.
48. Extley AR, Leese T, Holliday MP et al. Endotoxemia and
serum necrosis factor as prognostic markers in severe acute
pancreatitis. Gut 1992; 33:1126–1128.
49. Heath DL, Cruickshank DH, Gudgeon M et al. Role of
interleukin-6 in mediating the acute phase protein response
and potential as an means of severity assessment in acute
pancreatitis. Gut 1993; 66:41–45.
50. Rodriguez-Reynoso S, Leal C, Portilla E et al. Effect
of exogenous melatonin on hepatic energetic status during
ischemia/reperfusion possible role of tumor necrosis factoralpha
and nitric oxide. J Surg Res 2001; 100:141–149.
51. Wu CC, Chiao CW, Hsiao G et al. Melatonin prevents endotoxin-
induced failure in rats. J Pineal Res 2001; 30:147–156.
52. Baykat A, Iskit AB, Hamaloglou E et al. Melatonin
modulates mesenteric blood flow and TNFalpha concentra-

tions after lipopolysaccharide challenge. Eur J Surg 2000;
166:722–727.
53. Raghavendra V, Agrewala JN, Kulkarni SK. Melatonin
reversal of lipopolysaccharides-induced thermal and
behavioral hyperalgesia in mice. Eur J Pharmacol 2000;
395:15–21.

54. Shafer LL, McNulty JA, Young MR. Assessment of
melatonins ability to regulate cytokine production by macrophage
and microglia cell type. J Neuroimmunol 2001; 120:84–
93.

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